Synaptic
Nomad

Traveling through Asia to communicate
the synaptic priming framework.

May 29, 2025

Making synapses
with psychedelics

Dr. Brown hosts Dr. Alex Kwan, Associate Professor of Biomedical Engineering at Cornell University,
for a UM-MIND Seminar on the therapeutic, structural plasticity evoked by psychedelics.

March 17, 2025

Ketamine metabolite
primes plasticity

In this article, we show that rapid synaptic potentiation evoked by ketamine metabolite (2R,6R)-hydroxynorketamine persistently increases the ability for hippocampal synaptic plasticity, an effect previously attributed only to ketamine.

December 16, 2024

Dopamine and opioid
synaptic plasticity

Postsynaptic dopamine D3 receptors in the hippocampus are selectively targeted by inputs from ยต-opioid receptor-expressing GABAergic terminals, suggesting an inhibitory CA1 synapse is uniquely regulated by dopaminergic and opioidergic signaling.

July 24, 2023

Ketamine preservative
potentiates hippocampal synaptic strength

Some studies have shown that ketamine rapidly enhances hippocampal synaptic strength, but others found no effect. In this article, we show that a preservative in veterinary ketamine formulations potentiates synaptic strength, suggesting that it may be responsible for synaptic actions previously attributed to ketamine.